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Ulrike Philippar Selected Research

Neoplasms (Cancer)

12/2021Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.
12/2021Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.
8/2019Influence of the bispecific antibody IgG subclass on T cell redirection.
10/2018Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.
1/2016Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.
11/2015PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.
7/2013Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.
9/2011DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival.
1/2009Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.
12/2008A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.
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Ulrike Philippar Research Topics

Disease

11Neoplasms (Cancer)
12/2021 - 05/2005
2B-Cell Lymphoma (Lymphoma, B Cell)
12/2019 - 10/2018
2Melanoma (Melanoma, Malignant)
01/2016 - 07/2013
2Breast Neoplasms (Breast Cancer)
11/2015 - 12/2008
2Neoplasm Metastasis (Metastasis)
11/2015 - 12/2008
1Hematologic Neoplasms (Hematological Malignancy)
12/2021
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2021
1Non-Hodgkin Lymphoma (Lymphosarcoma)
12/2021
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
12/2021
1Bites and Stings (Sting)
08/2019
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
10/2018
1Liver Neoplasms (Liver Cancer)
09/2011
1Hepatocellular Carcinoma (Hepatoma)
09/2011
1Carcinoma (Carcinomatosis)
12/2008
1Adenocarcinoma
08/2008
1Pancreatic Neoplasms (Pancreatic Cancer)
08/2008

Drug/Important Bio-Agent (IBA)

4Protein Isoforms (Isoforms)IBA
11/2015 - 08/2008
2ErbB Receptors (EGF Receptor)IBA
08/2019 - 08/2008
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2016 - 07/2013
2Epidermal Growth Factor (EGF)IBA
11/2015 - 12/2008
2Biomarkers (Surrogate Marker)IBA
09/2011 - 01/2009
2Proteins (Proteins, Gene)FDA Link
01/2009 - 12/2008
1Phosphotransferases (Kinase)IBA
12/2021
1RNA Splicing FactorsIBA
12/2021
1JNJ-64619178IBA
12/2021
1Interleukin-6 (Interleukin 6)IBA
12/2019
1Bovine Serum AlbuminIBA
08/2019
1Bispecific AntibodiesIBA
08/2019
1Phosphates (Orthophosphate)IBA
08/2019
1Red Fluorescent ProteinIBA
08/2019
1PhycoerythrinIBA
08/2019
1Single-Chain AntibodiesIBA
08/2019
12-(N-morpholino)ethanesulfonic acidIBA
08/2019
1CationsIBA
08/2019
1Complement System Proteins (Complement)IBA
08/2019
1Coloring Agents (Dyes)IBA
08/2019
1Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinIBA
10/2018
1Urea (Carbamide)FDA LinkGeneric
01/2016
1compound 21IBA
01/2016
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
01/2016
1Messenger RNA (mRNA)IBA
11/2015
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2015
1SCH772984IBA
07/2013
1Mitogen-Activated Protein KinasesIBA
07/2013
1Fetal Proteins (Fetoprotein)IBA
09/2011
1Epithelial Cell Adhesion MoleculeIBA
09/2011
1MicroRNAs (MicroRNA)IBA
09/2011
1NestinIBA
09/2011
1Microfilament Proteins (Actin Binding Proteins)IBA
01/2009
1Erlotinib Hydrochloride (CP 358,774)FDA Link
08/2008
1Green Fluorescent ProteinsIBA
05/2005
1Cyan Fluorescent ProteinIBA
05/2005
1CollagenIBA
05/2005

Therapy/Procedure

1Therapeutics
08/2019